Mitochondrial ROS prime the hyperglycemic shift from apoptosis to necroptosis

We have previously identified a shift from TNF-α-induced apoptosis to necroptosis that occurs under hyperglycemic conditions. This shift involves the downregulation or silencing of caspases and concurrent upregulation of necroptotic proteins leading to activation of the necrosome. In addition, under...

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Detalles Bibliográficos
Autores principales: Deragon, Matthew A., McCaig, William D., Patel, Payal S., Haluska, Robert J., Hodges, Alexa L., Sosunov, Sergey A., Murphy, Michael P., Ten, Vadim S., LaRocca, Timothy J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7693268/
https://www.ncbi.nlm.nih.gov/pubmed/33298902
http://dx.doi.org/10.1038/s41420-020-00370-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7693268/
https://www.ncbi.nlm.nih.gov/pubmed/33298902
http://dx.doi.org/10.1038/s41420-020-00370-3

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