An Investigation of Structure-Activity Relationships of Azolylacryloyl Derivatives Yielded Potent and Long-Acting Hemoglobin Modulators for Reversing Erythrocyte Sickling

Aromatic aldehydes that bind to sickle hemoglobin (HbS) to increase the protein oxygen affinity and/or directly inhibit HbS polymer formation to prevent the pathological hypoxia-induced HbS polymerization and the subsequent erythrocyte sickling have for several years been studied for the treatment o...

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Detalles Bibliográficos
Autores principales: Omar, Abdelsattar M., Abdulmalik, Osheiza, Ghatge, Mohini S., Muhammad, Yosra A., Paredes, Steven D., El-Araby, Moustafa E., Safo, Martin K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7693414/
https://www.ncbi.nlm.nih.gov/pubmed/33147875
http://dx.doi.org/10.3390/biom10111508

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7693414/
https://www.ncbi.nlm.nih.gov/pubmed/33147875
http://dx.doi.org/10.3390/biom10111508

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