Multiplexed tat-Targeting CRISPR-Cas9 Protects T Cells from Acute HIV-1 Infection with Inhibition of Viral Escape

HIV-1 cure strategy by means of proviral knock-out using CRISPR-Cas9 has been hampered by the emergence of viral resistance against the targeting guide RNA (gRNA). Here, we proposed multiple, concentrated gRNA attacks against HIV-1 regulatory genes to block viral escape. The T cell line were transdu...

Descripción completa

Detalles Bibliográficos
Autores principales: Ophinni, Youdiil, Miki, Sayaka, Hayashi, Yoshitake, Kameoka, Masanori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7693572/
https://www.ncbi.nlm.nih.gov/pubmed/33126728
http://dx.doi.org/10.3390/v12111223

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7693572/
https://www.ncbi.nlm.nih.gov/pubmed/33126728
http://dx.doi.org/10.3390/v12111223

Ejemplares similares