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HIV-1 Uncoating and Nuclear Import Precede the Completion of Reverse Transcription in Cell Lines and in Primary Macrophages

An assembly of capsid proteins (CA) form the mature viral core enclosing the HIV-1 ribonucleoprotein complex. Discrepant findings have been reported regarding the cellular sites and the extent of core disassembly (uncoating) in infected cells. Here, we combined single-virus imaging and time-of-drug-...

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Detalles Bibliográficos
Autores principales: Francis, Ashwanth C., Marin, Mariana, Prellberg, Mathew J., Palermino-Rowland, Kristina, Melikyan, Gregory B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7693591/
https://www.ncbi.nlm.nih.gov/pubmed/33143125
http://dx.doi.org/10.3390/v12111234