OGG1 Inhibitor TH5487 Alters OGG1 Chromatin Dynamics and Prevents Incisions

8-oxoguanine DNA glycosylase (OGG1) is the main DNA glycosylase responsible for the excision of 7,8-dihydro-8-oxoguanine (8-oxoG) from duplex DNA to initiate base excision repair. This glycosylase activity is relevant in many pathological conditions including cancer, inflammation, and neurodegenerat...

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Detalles Bibliográficos
Autores principales: Hanna, Bishoy M. F., Helleday, Thomas, Mortusewicz, Oliver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7693665/
https://www.ncbi.nlm.nih.gov/pubmed/33114607
http://dx.doi.org/10.3390/biom10111483

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7693665/
https://www.ncbi.nlm.nih.gov/pubmed/33114607
http://dx.doi.org/10.3390/biom10111483

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