TLR9 Binding to Beclin 1 and Mitochondrial SIRT3 by a Sodium-Glucose Co-Transporter 2 Inhibitor Protects the Heart from Doxorubicin Toxicity

SIMPLE SUMMARY: We described the existence of an integrated Beclin 1, TLR9, and SIRT3 network involving autophagy, oxidative stress, and mitochondria that is essential for empagliflozin to protect against doxorubicin toxicity in the heart. Empagliflozin treatment increases the abundance of mitochond...

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Detalles Bibliográficos
Autores principales: Wang, Chao-Yung, Chen, Chun-Chi, Lin, Mei-Hsiu, Su, Hui-Ting, Ho, Ming-Yun, Yeh, Jih-Kai, Tsai, Ming-Lung, Hsieh, I-Chang, Wen, Ming-Shien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7693736/
https://www.ncbi.nlm.nih.gov/pubmed/33138323
http://dx.doi.org/10.3390/biology9110369

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7693736/
https://www.ncbi.nlm.nih.gov/pubmed/33138323
http://dx.doi.org/10.3390/biology9110369

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