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TLR9 Binding to Beclin 1 and Mitochondrial SIRT3 by a Sodium-Glucose Co-Transporter 2 Inhibitor Protects the Heart from Doxorubicin Toxicity
SIMPLE SUMMARY: We described the existence of an integrated Beclin 1, TLR9, and SIRT3 network involving autophagy, oxidative stress, and mitochondria that is essential for empagliflozin to protect against doxorubicin toxicity in the heart. Empagliflozin treatment increases the abundance of mitochond...
Autores principales: | Wang, Chao-Yung, Chen, Chun-Chi, Lin, Mei-Hsiu, Su, Hui-Ting, Ho, Ming-Yun, Yeh, Jih-Kai, Tsai, Ming-Lung, Hsieh, I-Chang, Wen, Ming-Shien |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7693736/ https://www.ncbi.nlm.nih.gov/pubmed/33138323 http://dx.doi.org/10.3390/biology9110369 |
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