Development of Self-Associating SN-38-Conjugated Poly(ethylene oxide)-Poly(ester) Micelles for Colorectal Cancer Therapy

The clinical use of 7-ethyl-10-hydroxy-camptothecin (SN-38), which is the active metabolite of irinotecan, has been hampered because of its practical water-insolubility. In this study, we successfully synthesized two self-associating SN-38-polymer drug conjugates to improve the water-solubility of S...

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Detalles Bibliográficos
Autores principales: Sadat, Sams M. A., Vakili, Mohammad Reza, Paiva, Igor M., Weinfeld, Michael, Lavasanifar, Afsaneh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7694018/
https://www.ncbi.nlm.nih.gov/pubmed/33138058
http://dx.doi.org/10.3390/pharmaceutics12111033

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7694018/
https://www.ncbi.nlm.nih.gov/pubmed/33138058
http://dx.doi.org/10.3390/pharmaceutics12111033

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