An allosteric interleukin-1 receptor modulator mitigates inflammation and photoreceptor toxicity in a model of retinal degeneration

BACKGROUND: Inflammation and particularly interleukin-1β (IL-1β), a pro-inflammatory cytokine highly secreted by activated immune cells during early AMD pathological events, contribute significantly to retinal neurodegeneration. Here, we identify specific cell types that generate IL-1β and harbor th...

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Detalles Bibliográficos
Autores principales: Dabouz, Rabah, Cheng, Colin W. H., Abram, Pénélope, Omri, Samy, Cagnone, Gael, Sawmy, Khushnouma Virah, Joyal, Jean-Sébastien, Desjarlais, Michel, Olson, David, Weil, Alexander G., Lubell, William, Rivera, José Carlos, Chemtob, Sylvain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7694438/
https://www.ncbi.nlm.nih.gov/pubmed/33246504
http://dx.doi.org/10.1186/s12974-020-02032-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7694438/
https://www.ncbi.nlm.nih.gov/pubmed/33246504
http://dx.doi.org/10.1186/s12974-020-02032-8

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