HIV-1 promoter is gradually silenced when integrated into BACH2 in Jurkat T-cells

BACKGROUND: The persistence of the latent HIV-1 reservoir is a major obstacle to curing HIV-1 infection. HIV-1 integrates into the cellular genome and some targeted genomic loci are frequently detected in clonally expanded latently HIV-1 infected cells, for instance, the gene BTB domain and CNC homo...

Descripción completa

Detalles Bibliográficos
Autores principales: Inderbitzin, Anne, Kok, Yik Lim, Jörimann, Lisa, Kelley, Audrey, Neumann, Kathrin, Heinzer, Daniel, Cathomen, Toni, Metzner, Karin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2020
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7694569/
https://www.ncbi.nlm.nih.gov/pubmed/33282555
http://dx.doi.org/10.7717/peerj.10321

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7694569/
https://www.ncbi.nlm.nih.gov/pubmed/33282555
http://dx.doi.org/10.7717/peerj.10321

Ejemplares similares