Synthesis, 3D-QSAR, and Molecular Modeling Studies of Triazole Bearing Compounds as a Promising Scaffold for Cyclooxygenase-2 Inhibition

Targeting of cyclooxygenase-2 (COX-2) has emerged as a powerful tool for therapeutic intervention because the overexpression of this enzyme is synonymous with inflammation, cancer, and neurodegenerative diseases. Herein, a new series of 1,2,4-triazole Schiff bases scaffold with aryl and heteroaryl s...

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Detalles Bibliográficos
Autores principales: Elrayess, Ranza, Elgawish, Mohamed Saleh, Elewa, Marwa, Nafie, Mohamed S., Elhady, Sameh S., Yassen, Asmaa S. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7694773/
https://www.ncbi.nlm.nih.gov/pubmed/33172102
http://dx.doi.org/10.3390/ph13110370

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7694773/
https://www.ncbi.nlm.nih.gov/pubmed/33172102
http://dx.doi.org/10.3390/ph13110370

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