Targeted nanobody complex enhanced photodynamic therapy for lung cancer by overcoming tumor microenvironment

BACKGROUND: To investigate the efficacy of a PLGA-based nanobody complex in photodynamic therapy (PDT) and NIR-II imaging in A549 tumor hypoxic model. METHOD: IR1048-MZ was firstly synthesized by conjugating a nitro imidazole group to IR1048. IR1048-MZ and Cat were then encapsulated in PLGA-SH solut...

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Detalles Bibliográficos
Autores principales: Zhang, Qing, Wu, Lian, Liu, Shaozheng, Chen, Qingjie, Zeng, Lingpeng, Chen, Xuezhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Primary Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7694906/
https://www.ncbi.nlm.nih.gov/pubmed/33292202
http://dx.doi.org/10.1186/s12935-020-01613-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7694906/
https://www.ncbi.nlm.nih.gov/pubmed/33292202
http://dx.doi.org/10.1186/s12935-020-01613-0

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