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Targeted nanobody complex enhanced photodynamic therapy for lung cancer by overcoming tumor microenvironment

BACKGROUND: To investigate the efficacy of a PLGA-based nanobody complex in photodynamic therapy (PDT) and NIR-II imaging in A549 tumor hypoxic model. METHOD: IR1048-MZ was firstly synthesized by conjugating a nitro imidazole group to IR1048. IR1048-MZ and Cat were then encapsulated in PLGA-SH solut...

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Detalles Bibliográficos
Autores principales:	Zhang, Qing, Wu, Lian, Liu, Shaozheng, Chen, Qingjie, Zeng, Lingpeng, Chen, Xuezhong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Primary Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7694906/ https://www.ncbi.nlm.nih.gov/pubmed/33292202 http://dx.doi.org/10.1186/s12935-020-01613-0

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