Darunavir-Resistant HIV-1 Protease Constructs Uphold a Conformational Selection Hypothesis for Drug Resistance

Multidrug resistance continues to be a barrier to the effectiveness of highly active antiretroviral therapy in the treatment of human immunodeficiency virus 1 (HIV-1) infection. Darunavir (DRV) is a highly potent protease inhibitor (PI) that is oftentimes effective when drug resistance has emerged a...

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Detalles Bibliográficos
Autores principales: Liu, Zhanglong, Tran, Trang T., Pham, Linh, Hu, Lingna, Bentz, Kyle, Savin, Daniel A., Fanucci, Gail E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7695139/
https://www.ncbi.nlm.nih.gov/pubmed/33171603
http://dx.doi.org/10.3390/v12111275

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7695139/
https://www.ncbi.nlm.nih.gov/pubmed/33171603
http://dx.doi.org/10.3390/v12111275

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