Combining Co-Amorphous-Based Spray Drying with Inert Carriers to Achieve Improved Bioavailability and Excellent Downstream Manufacturability

It is crucial to improve poorly water-soluble orally administered drugs through both preclinical and therapeutic drug discovery. A co-amorphous formulation consisting of two low molecular weight (MW) molecules offers a solubility/dissolubility advantage over its crystalline form by maintaining their...

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Detalles Bibliográficos
Autores principales: Zhang, Yingxi, Gao, Yuan, Du, Xiaoxiao, Guan, Rou, He, Zhonggui, Liu, Hongzhuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7695141/
https://www.ncbi.nlm.nih.gov/pubmed/33171591
http://dx.doi.org/10.3390/pharmaceutics12111063

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7695141/
https://www.ncbi.nlm.nih.gov/pubmed/33171591
http://dx.doi.org/10.3390/pharmaceutics12111063

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