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Combining Co-Amorphous-Based Spray Drying with Inert Carriers to Achieve Improved Bioavailability and Excellent Downstream Manufacturability

It is crucial to improve poorly water-soluble orally administered drugs through both preclinical and therapeutic drug discovery. A co-amorphous formulation consisting of two low molecular weight (MW) molecules offers a solubility/dissolubility advantage over its crystalline form by maintaining their...

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Detalles Bibliográficos
Autores principales:	Zhang, Yingxi, Gao, Yuan, Du, Xiaoxiao, Guan, Rou, He, Zhonggui, Liu, Hongzhuo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7695141/ https://www.ncbi.nlm.nih.gov/pubmed/33171591 http://dx.doi.org/10.3390/pharmaceutics12111063

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