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The Importance of Poly(ethylene glycol) and Lipid Structure in Targeted Gene Delivery to Lymph Nodes by Lipid Nanoparticles
Targeted delivery of nucleic acids to lymph nodes is critical for the development of effective vaccines and immunotherapies. However, it remains challenging to achieve selective lymph node delivery. Current gene delivery systems target mainly to the liver and typically exhibit off-target transfectio...
Autores principales: | Zukancic, Danijela, Suys, Estelle J. A., Pilkington, Emily H., Algarni, Azizah, Al-Wassiti, Hareth, Truong, Nghia P. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7695259/ https://www.ncbi.nlm.nih.gov/pubmed/33182382 http://dx.doi.org/10.3390/pharmaceutics12111068 |
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