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Sirtuin 6 deficiency induces endothelial cell senescence via downregulation of forkhead box M1 expression
Cellular senescence of endothelial cells causes vascular dysfunction, promotes atherosclerosis, and contributes to the development of age-related vascular diseases. Sirtuin 6 (SIRT6), a conserved NAD+-dependent protein deacetylase, has beneficial effects against aging, despite the fact that its func...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7695388/ https://www.ncbi.nlm.nih.gov/pubmed/33171439 http://dx.doi.org/10.18632/aging.202176 |