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Coinhibition of activated p38 MAPKα and mTORC1 potentiates stemness maintenance of HSCs from SR1‐expanded human cord blood CD34 (+) cells via inhibition of senescence
The stemness of ex vivo expanded hematopoietic stem cells (HSCs) is usually compromised by current methods. To explore the failure mechanism of stemness maintenance of human HSCs, which were expanded from human umbilical cord blood (hUCB) CD34(+) cells, by differentiation inhibitor Stem Regenin 1 (S...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7695631/ https://www.ncbi.nlm.nih.gov/pubmed/32602209 http://dx.doi.org/10.1002/sctm.20-0129 |