Coinhibition of activated p38 MAPKα and mTORC1 potentiates stemness maintenance of HSCs from SR1‐expanded human cord blood CD34 (+) cells via inhibition of senescence

The stemness of ex vivo expanded hematopoietic stem cells (HSCs) is usually compromised by current methods. To explore the failure mechanism of stemness maintenance of human HSCs, which were expanded from human umbilical cord blood (hUCB) CD34(+) cells, by differentiation inhibitor Stem Regenin 1 (S...

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Detalles Bibliográficos
Autores principales: Li, Xiaoyi, Ma, Xiao, Chen, Ying, Peng, Danyue, Wang, Huifang, Chen, Suhua, Xiao, Yin, Li, Lei, Zhou, Hao, Cheng, Fanjun, Gao, Yingdai, Chang, Jiwei, Cheng, Tao, Liu, Lingbo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2020
Materias:
Tissue Engineering and Regenerative Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7695631/
https://www.ncbi.nlm.nih.gov/pubmed/32602209
http://dx.doi.org/10.1002/sctm.20-0129

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