Quaternary Structure Changes for PrP(Sc) Predate PrP(C) Downregulation and Neuronal Death During Progression of Experimental Scrapie Disease

Prion diseases are fatal neurodegenerative diseases in mammals with the unique characteristics of misfolding and aggregation of the cellular prion protein (PrP(C)) to the scrapie prion (PrP(Sc)). Although neuroinflammation and neuronal loss feature within the disease process, the details of PrP(C)/P...

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Detalles Bibliográficos
Autores principales: Eskandari-Sedighi, Ghazaleh, Cortez, Leonardo M., Yang, Jing, Daude, Nathalie, Shmeit, Klinton, Sim, Valerie, Westaway, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7695655/
https://www.ncbi.nlm.nih.gov/pubmed/32959170
http://dx.doi.org/10.1007/s12035-020-02112-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7695655/
https://www.ncbi.nlm.nih.gov/pubmed/32959170
http://dx.doi.org/10.1007/s12035-020-02112-z

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