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Aniline-containing derivatives of parthenolide: Synthesis and anti-chronic lymphocytic leukaemia activity

Parthenolide exhibits anti-leukaemia activity, whilst its synthetic modification to impart improve drug-like properties, including 1,4-conjugate addition of primary and secondary amines, have previously been used, 1,4-addition of aniline derivatives to parthenolide has not been fully explored. A pro...

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Detalles Bibliográficos
Autores principales: Quy, Alex S., Li, Xingjian, Male, Louise, Stankovic, Tatjana, Agathanggelou, Angelo, Fossey, John S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pergamon Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7695678/
https://www.ncbi.nlm.nih.gov/pubmed/33299257
http://dx.doi.org/10.1016/j.tet.2020.131631