The PAR2 inhibitor I-287 selectively targets Gα(q) and Gα(12/13) signaling and has anti-inflammatory effects

Protease-activated receptor-2 (PAR2) is involved in inflammatory responses and pain, therefore representing a promising therapeutic target for the treatment of immune-mediated inflammatory diseases. However, as for other GPCRs, PAR2 can activate multiple signaling pathways and those involved in infl...

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Detalles Bibliográficos
Autores principales: Avet, Charlotte, Sturino, Claudio, Grastilleur, Sébastien, Gouill, Christian Le, Semache, Meriem, Gross, Florence, Gendron, Louis, Bennani, Youssef, Mancini, Joseph A., Sayegh, Camil E., Bouvier, Michel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7695697/
https://www.ncbi.nlm.nih.gov/pubmed/33247181
http://dx.doi.org/10.1038/s42003-020-01453-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7695697/
https://www.ncbi.nlm.nih.gov/pubmed/33247181
http://dx.doi.org/10.1038/s42003-020-01453-8

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