Mechanism and inhibition of Streptococcus pneumoniae IgA1 protease

Opportunistic pathogens such as Streptococcus pneumoniae secrete a giant metalloprotease virulence factor responsible for cleaving host IgA1, yet the molecular mechanism has remained unknown since their discovery nearly 30 years ago despite the potential for developing vaccines that target these enz...

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Detalles Bibliográficos
Autores principales: Wang, Zhiming, Rahkola, Jeremy, Redzic, Jasmina S., Chi, Ying-Chih, Tran, Norman, Holyoak, Todd, Zheng, Hongjin, Janoff, Edward, Eisenmesser, Elan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7695701/
https://www.ncbi.nlm.nih.gov/pubmed/33247098
http://dx.doi.org/10.1038/s41467-020-19887-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7695701/
https://www.ncbi.nlm.nih.gov/pubmed/33247098
http://dx.doi.org/10.1038/s41467-020-19887-3

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