Transcription-dependent cohesin repositioning rewires chromatin loops in cellular senescence

Senescence is a state of stable proliferative arrest, generally accompanied by the senescence-associated secretory phenotype, which modulates tissue homeostasis. Enhancer-promoter interactions, facilitated by chromatin loops, play a key role in gene regulation but their relevance in senescence remai...

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Detalles Bibliográficos
Autores principales: Olan, Ioana, Parry, Aled J., Schoenfelder, Stefan, Narita, Masako, Ito, Yoko, Chan, Adelyne S. L., Slater, Guy St.C., Bihary, Dóra, Bando, Masashige, Shirahige, Katsuhiko, Kimura, Hiroshi, Samarajiwa, Shamith A., Fraser, Peter, Narita, Masashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7695716/
https://www.ncbi.nlm.nih.gov/pubmed/33247104
http://dx.doi.org/10.1038/s41467-020-19878-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7695716/
https://www.ncbi.nlm.nih.gov/pubmed/33247104
http://dx.doi.org/10.1038/s41467-020-19878-4

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