CRISPR based editing of SIV proviral DNA in ART treated non-human primates

Elimination of HIV DNA from infected individuals remains a challenge in medicine. Here, we demonstrate that intravenous inoculation of SIV-infected macaques, a well-accepted non-human primate model of HIV infection, with adeno-associated virus 9 (AAV9)-CRISPR/Cas9 gene editing construct designed for...

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Detalles Bibliográficos
Autores principales: Mancuso, Pietro, Chen, Chen, Kaminski, Rafal, Gordon, Jennifer, Liao, Shuren, Robinson, Jake A., Smith, Mandy D., Liu, Hong, Sariyer, Ilker K., Sariyer, Rahsan, Peterson, Tiffany A., Donadoni, Martina, Williams, Jaclyn B., Siddiqui, Summer, Bunnell, Bruce A., Ling, Binhua, MacLean, Andrew G., Burdo, Tricia H., Khalili, Kamel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7695718/
https://www.ncbi.nlm.nih.gov/pubmed/33247091
http://dx.doi.org/10.1038/s41467-020-19821-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7695718/
https://www.ncbi.nlm.nih.gov/pubmed/33247091
http://dx.doi.org/10.1038/s41467-020-19821-7

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