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In vitro-transcribed antigen receptor mRNA nanocarriers for transient expression in circulating T cells in vivo
Engineering chimeric antigen receptors (CAR) or T cell receptors (TCR) helps create disease-specific T cells for targeted therapy, but the cost and rigor associated with manufacturing engineered T cells ex vivo can be prohibitive, so programing T cells in vivo may be a viable alternative. Here we re...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7695830/ https://www.ncbi.nlm.nih.gov/pubmed/33247092 http://dx.doi.org/10.1038/s41467-020-19486-2 |