Synthesis of New 1, 3, 4-Oxadiazole-Incorporated 1, 2, 3-Triazole Moieties as Potential Anticancer Agents Targeting Thymidylate Synthase and Their Docking Studies

Thymidylate synthase (TS) has emerged as a hot spot in cancer treatment, as it is directly involved in DNA synthesis. In the present article, nine hybrids containing 1,2,3-triazole and 1,3,4-oxadiazole moieties (6–14) were synthesized and evaluated for anticancer and in vitro thymidylate synthase ac...

Descripción completa

Detalles Bibliográficos
Autores principales: Alam, Mohammad Mahboob, Almalki, Abdulraheem SA, Neamatallah, Thikryat, Ali, Nada M., Malebari, Azizah M., Nazreen, Syed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7696185/
https://www.ncbi.nlm.nih.gov/pubmed/33202652
http://dx.doi.org/10.3390/ph13110390

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7696185/
https://www.ncbi.nlm.nih.gov/pubmed/33202652
http://dx.doi.org/10.3390/ph13110390

Ejemplares similares