Cargando…

Synthesis of New 1, 3, 4-Oxadiazole-Incorporated 1, 2, 3-Triazole Moieties as Potential Anticancer Agents Targeting Thymidylate Synthase and Their Docking Studies

Thymidylate synthase (TS) has emerged as a hot spot in cancer treatment, as it is directly involved in DNA synthesis. In the present article, nine hybrids containing 1,2,3-triazole and 1,3,4-oxadiazole moieties (6–14) were synthesized and evaluated for anticancer and in vitro thymidylate synthase ac...

Descripción completa

Detalles Bibliográficos
Autores principales:	Alam, Mohammad Mahboob, Almalki, Abdulraheem SA, Neamatallah, Thikryat, Ali, Nada M., Malebari, Azizah M., Nazreen, Syed
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7696185/ https://www.ncbi.nlm.nih.gov/pubmed/33202652 http://dx.doi.org/10.3390/ph13110390

Ejemplares similares

Design, synthesis and in vitro antiproliferative activity of new thiazolidinedione-1,3,4-oxadiazole hybrids as thymidylate synthase inhibitors
por: Alzhrani, Zohor Mohammad Mahdi, et al.
Publicado: (2020)

Synthesis and Biological Evaluation of 1,2,3-Triazole Tethered Thymol-1,3,4-Oxadiazole Derivatives as Anticancer and Antimicrobial Agents
por: Almalki, Abdulraheem S. A., et al.
Publicado: (2021)

Naproxen Based 1,3,4-Oxadiazole Derivatives as EGFR Inhibitors: Design, Synthesis, Anticancer, and Computational Studies
por: Alam, Mohammad Mahboob, et al.
Publicado: (2021)

In silico ADME predictions and in vitro antibacterial evaluation of 2-hydroxy benzothiazole-based 1,3,4-oxadiazole derivatives
por: ALGHAMDI, Afnan Ahmed, et al.
Publicado: (2020)

Andrographolide nanophytosomes exhibit enhanced cellular delivery and pro-apoptotic activities in HepG2 liver cancer cells
por: Neamatallah, Thikryat, et al.
Publicado: (2023)

Design, synthesis, anticancer evaluation and molecular docking studies of 1,2,3-triazole incorporated 1,3,4-oxadiazole-Triazine derivatives
por: Oggu, Sujana, et al.
Publicado: (2023)

Antibacterial Activities and Molecular Docking of Novel Sulfone Biscompound Containing Bioactive 1,2,3-Triazole Moiety
por: Rashdan, Huda R. M., et al.
Publicado: (2021)

Synthesis and Biological Activities of Ethyl 2-(2-pyridylacetate) Derivatives Containing Thiourea, 1,2,4-triazole, Thiadiazole and Oxadiazole Moieties
por: Szulczyk, Daniel, et al.
Publicado: (2017)

Molecular docking studies on quinazoline antifolate derivatives as human thymidylate synthase inhibitors
por: Srivastava, Vivek, et al.
Publicado: (2010)

Synthesis and Antifungal Activity of Novel Sulfone Derivatives Containing 1,3,4-Oxadiazole Moieties
por: Xu, Weiming, et al.
Publicado: (2011)

Insights on Cancer Cell Inhibition, Subcellular Activities, and Kinase Profile of Phenylacetamides Pending 1H-Imidazol-5-One Variants
por: Khayat, Maan T., et al.
Publicado: (2022)

Effect of Hammerhead Ribozyme against Human Thymidylate Synthase on the Cytotoxicity of Thymidylate Synthase Inhibitors
por: Kobayashi, Hiroyuki, et al.
Publicado: (1995)

Synthesis and Antibacterial Evaluation of Novel 1,3,4-Oxadiazole Derivatives Containing Sulfonate/Carboxylate Moiety
por: Wang, Lei, et al.
Publicado: (2020)

Trichinella pseudospiralis vs. T. spiralis thymidylate synthase gene structure and T. pseudospiralis thymidylate synthase retrogene sequence
por: Jagielska, Elżbieta, et al.
Publicado: (2014)

Phenoxyalkylimidazoles with an oxadiazole moiety are subject to efflux in Mycobacterium tuberculosis
por: Thayer, Mai B., et al.
Publicado: (2021)

Semisynthesis and insecticidal activity of some novel fraxinellone-based thioethers containing 1,3,4-oxadiazole moiety
por: Guo, Yong, et al.
Publicado: (2017)

Synthesis and pesticidal activity of new 1,3,4-oxadiazole thioether compounds containing a trifluoromethylpyrazoyl moiety
por: Shi, Hai-Bo, et al.
Publicado: (2022)

Synthesis and Antifungal Activity of Benzamidine Derivatives Carrying 1,2,3-Triazole Moieties
por: Chen, Guangyou, et al.
Publicado: (2014)

Synthesis, Anti-proliferative Activity, and Molecular Docking Study of New Series of 1,3-5-Triazine Schiff Base Derivatives
por: Al Rasheed, Hessa H., et al.
Publicado: (2020)

3′-UTR Polymorphisms in Thymidylate Synthase with Colorectal Cancer Prevalence and Prognosis
por: Jeon, Young-Joo, et al.
Publicado: (2021)

Conservation and Role of Electrostatics in Thymidylate Synthase
por: Garg, Divita, et al.
Publicado: (2015)

Molecular Docking, Computational, and Antithrombotic Studies of Novel 1,3,4-Oxadiazole Derivatives
por: Batool, Majda, et al.
Publicado: (2018)

Mitogen-Activated Protein Kinase Pathway: A Critical Regulator in Tumor-associated Macrophage Polarization
por: Neamatallah, Thikryat
Publicado: (2019)

Delayed inflammatory reaction to hyaluronic acid lip filler after the Pfizer-BioNTech COVID-19 vaccine: A case report
por: Neamatallah, Thikryat
Publicado: (2023)

Synthesis and In Vitro Antimicrobial Evaluation of New 1,3,4-Oxadiazoles Bearing 5-Chloro-2-methoxyphenyl Moiety
por: Prasanna Kumar, Basavapatna N., et al.
Publicado: (2013)

Synthesis and Antibacterial Evaluation of New Sulfone Derivatives Containing 2-Aroxymethyl-1,3,4-Oxadiazole/Thiadiazole Moiety
por: Su, Shihu, et al.
Publicado: (2016)

Synthesis, analgesic and anti-inflammatory activities of new methyl-imidazolyl-1,3,4-oxadiazoles and 1,2,4-triazoles
por: Almasirad, Ali, et al.
Publicado: (2014)

Substrate Activation in Flavin-Dependent Thymidylate Synthase
por: Mishanina, Tatiana V., et al.
Publicado: (2014)

Concerted versus Stepwise Mechanism in Thymidylate Synthase
por: Islam, Zahidul, et al.
Publicado: (2014)

Cell Cycle Arrest and Apoptosis-Inducing Ability of Benzimidazole Derivatives: Design, Synthesis, Docking, and Biological Evaluation
por: Nazreen, Syed, et al.
Publicado: (2022)

Synthesis and Antioxidant Activity of 2-Amino-5-methylthiazol Derivatives Containing 1,3,4-Oxadiazole-2-thiol Moiety
por: Mohana, Kikkeri N., et al.
Publicado: (2013)

Novel 1,3,4-Oxadiazole Derivatives Containing a Cinnamic Acid Moiety as Potential Bactericide for Rice Bacterial Diseases
por: Wang, Shaobo, et al.
Publicado: (2019)

Antibacterial Activity and Mechanism of Action of Sulfone Derivatives Containing 1,3,4-Oxadiazole Moieties on Rice Bacterial Leaf Blight
por: Shi, Li, et al.
Publicado: (2015)

Design, Synthesis, In Vivo, and In Silico Evaluation of Benzothiazoles Bearing a 1,3,4-Oxadiazole Moiety as New Antiepileptic Agents
por: Chauhan, Bharti, et al.
Publicado: (2023)

Synthesis of Some New 1,3,4-Thiadiazole, Thiazole and Pyridine Derivatives Containing 1,2,3-Triazole Moiety
por: Abdelriheem, Nadia A., et al.
Publicado: (2017)

Design, synthesis, insecticidal activity and 3D-QSR study for novel trifluoromethyl pyridine derivatives containing an 1,3,4-oxadiazole moiety
por: Xu, F. Z., et al.
Publicado: (2018)

Discovery of novel quinoline-based analogues of combretastatin A-4 as tubulin polymerisation inhibitors with apoptosis inducing activity and potent anticancer effect
por: Ibrahim, Tarek S., et al.
Publicado: (2021)

4-[4-(4-Amino-1,2,5-oxadiazol-3-yl)-1,2,5-oxadiazol-3-yl]-1,2,5-oxadiazol-3-amine
por: Jia, Si-Yuan, et al.
Publicado: (2012)

Synthesis and Antiproliferative Evaluation of Novel Hybrids of Dehydroabietic Acid Bearing 1,2,3-Triazole Moiety
por: Li, Fang-Yao, et al.
Publicado: (2019)

2-(1,2,4-triazole-5-yl)-1,3,4-oxadiazole as a novel building block for energetic materials
por: Dong, Zheting, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_pa05r48q3tmcsk0e35ub283spr