Synthesis of Polyheterocyclic Dimers Containing Restricted and Constrained Peptidomimetics via IMCR-Based Domino/Double CuAAC Click Strategy

A novel strategy via the triple process (multicomponent reactions (MCR)-domino)/tandem was developed for the synthesis of restricted and constrained bis-1,2,3-triazole-linked pyrrolo[3,4-b]pyridine peptidomimetics dimers in overall yields of 20–55%. This strategy allows the construction of six heter...

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Autores principales: Pharande, Shrikant G., Rentería-Gómez, Manuel A., Gámez-Montaño, Rocío
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7696539/
https://www.ncbi.nlm.nih.gov/pubmed/33187075
http://dx.doi.org/10.3390/molecules25225246
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author Pharande, Shrikant G.
Rentería-Gómez, Manuel A.
Gámez-Montaño, Rocío
author_facet Pharande, Shrikant G.
Rentería-Gómez, Manuel A.
Gámez-Montaño, Rocío
author_sort Pharande, Shrikant G.
collection PubMed
description A novel strategy via the triple process (multicomponent reactions (MCR)-domino)/tandem was developed for the synthesis of restricted and constrained bis-1,2,3-triazole-linked pyrrolo[3,4-b]pyridine peptidomimetics dimers in overall yields of 20–55%. This strategy allows the construction of six heterocycles in two stages of the reaction.
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spelling pubmed-76965392020-11-29 Synthesis of Polyheterocyclic Dimers Containing Restricted and Constrained Peptidomimetics via IMCR-Based Domino/Double CuAAC Click Strategy Pharande, Shrikant G. Rentería-Gómez, Manuel A. Gámez-Montaño, Rocío Molecules Article A novel strategy via the triple process (multicomponent reactions (MCR)-domino)/tandem was developed for the synthesis of restricted and constrained bis-1,2,3-triazole-linked pyrrolo[3,4-b]pyridine peptidomimetics dimers in overall yields of 20–55%. This strategy allows the construction of six heterocycles in two stages of the reaction. MDPI 2020-11-11 /pmc/articles/PMC7696539/ /pubmed/33187075 http://dx.doi.org/10.3390/molecules25225246 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Pharande, Shrikant G.
Rentería-Gómez, Manuel A.
Gámez-Montaño, Rocío
Synthesis of Polyheterocyclic Dimers Containing Restricted and Constrained Peptidomimetics via IMCR-Based Domino/Double CuAAC Click Strategy
title Synthesis of Polyheterocyclic Dimers Containing Restricted and Constrained Peptidomimetics via IMCR-Based Domino/Double CuAAC Click Strategy
title_full Synthesis of Polyheterocyclic Dimers Containing Restricted and Constrained Peptidomimetics via IMCR-Based Domino/Double CuAAC Click Strategy
title_fullStr Synthesis of Polyheterocyclic Dimers Containing Restricted and Constrained Peptidomimetics via IMCR-Based Domino/Double CuAAC Click Strategy
title_full_unstemmed Synthesis of Polyheterocyclic Dimers Containing Restricted and Constrained Peptidomimetics via IMCR-Based Domino/Double CuAAC Click Strategy
title_short Synthesis of Polyheterocyclic Dimers Containing Restricted and Constrained Peptidomimetics via IMCR-Based Domino/Double CuAAC Click Strategy
title_sort synthesis of polyheterocyclic dimers containing restricted and constrained peptidomimetics via imcr-based domino/double cuaac click strategy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7696539/
https://www.ncbi.nlm.nih.gov/pubmed/33187075
http://dx.doi.org/10.3390/molecules25225246
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