The Rationale for Angiotensin Receptor Neprilysin Inhibitors in a Multi-Targeted Therapeutic Approach to COVID-19

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease (COVID-19) determines the angiotensin converting enzyme 2 (ACE2) down-regulation and related decrease in angiotensin II degradation. Both these events trigger “cytokine storm” leading to acute lung and cardiovascular injury. A...

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Detalles Bibliográficos
Autores principales: Bellis, Alessandro, Mauro, Ciro, Barbato, Emanuele, Trimarco, Bruno, Morisco, Carmine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7696732/
https://www.ncbi.nlm.nih.gov/pubmed/33203141
http://dx.doi.org/10.3390/ijms21228612

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7696732/
https://www.ncbi.nlm.nih.gov/pubmed/33203141
http://dx.doi.org/10.3390/ijms21228612

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