A Physiologically-Based Pharmacokinetic Model of Trimethoprim for MATE1, OCT1, OCT2, and CYP2C8 Drug–Drug–Gene Interaction Predictions

Trimethoprim is a frequently-prescribed antibiotic and therefore likely to be co-administered with other medications, but it is also a potent inhibitor of multidrug and toxin extrusion protein (MATE) and a weak inhibitor of cytochrome P450 (CYP) 2C8. The aim of this work was to develop a physiologic...

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Detalles Bibliográficos
Autores principales: Türk, Denise, Hanke, Nina, Lehr, Thorsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7696733/
https://www.ncbi.nlm.nih.gov/pubmed/33182761
http://dx.doi.org/10.3390/pharmaceutics12111074

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7696733/
https://www.ncbi.nlm.nih.gov/pubmed/33182761
http://dx.doi.org/10.3390/pharmaceutics12111074

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