Radiation Induced Upregulation of DNA Sensing Pathways is Cell-Type Dependent and Can Mediate the Off-Target Effects

SIMPLE SUMMARY: Radiotherapy was shown to act as in situ vaccination, which can mediate systemic response to cancer in conjunction with immune checkpoint inhibitors. We aimed to investigate the DNA sensing pathways as a fundamental mechanism of immunostimulation by DNA after tumor irradiation. Key d...

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Detalles Bibliográficos
Autores principales: Jesenko, Tanja, Bosnjak, Masa, Markelc, Bostjan, Sersa, Gregor, Znidar, Katarina, Heller, Loree, Cemazar, Maja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7696780/
https://www.ncbi.nlm.nih.gov/pubmed/33202881
http://dx.doi.org/10.3390/cancers12113365

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7696780/
https://www.ncbi.nlm.nih.gov/pubmed/33202881
http://dx.doi.org/10.3390/cancers12113365

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