Cargando…

Cinnamides Target Leishmania amazonensis Arginase Selectively

Caffeic acid and related natural compounds were previously described as Leishmania amazonensis arginase (L-ARG) inhibitors, and against the whole parasite in vitro. In this study, we tested cinnamides that were previously synthesized to target human arginase. The compound caffeic acid phenethyl amid...

Descripción completa

Detalles Bibliográficos
Autores principales:	da Silva, Edson Roberto, Come, Júlio Abel Alfredo dos Santos Simone, Brogi, Simone, Calderone, Vincenzo, Chemi, Giulia, Campiani, Giuseppe, Oliveira, Trícia Maria Ferrreira de Sousa, Pham, Thanh-Nhat, Pudlo, Marc, Girard, Corine, Maquiaveli, Claudia do Carmo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7696938/ https://www.ncbi.nlm.nih.gov/pubmed/33198198 http://dx.doi.org/10.3390/molecules25225271

Ejemplares similares

In Vitro and In Silico Analyses of New Cinnamid and Rosmarinic Acid-Derived Compounds Biosynthesized in Escherichia coli as Leishmania amazonensis Arginase Inhibitors
por: Come, Julio Abel Alfredo dos Santos Simone, et al.
Publicado: (2022)

Cinnamide Derivatives as Mammalian Arginase Inhibitors: Synthesis, Biological Evaluation and Molecular Docking
por: Pham, Thanh-Nhat, et al.
Publicado: (2016)

Inhibition of Leishmania (Leishmania) amazonensis and Rat Arginases by Green Tea EGCG, (+)-Catechin and (−)-Epicatechin: A Comparative Structural Analysis of Enzyme-Inhibitor Interactions
por: dos Reis, Matheus Balduíno Goncalves, et al.
Publicado: (2013)

Effect of piplartine and cinnamides on Leishmania amazonensis, Plasmodium falciparum and on peritoneal cells of Swiss mice
por: de Araújo-Vilges, Keline Medeiros, et al.
Publicado: (2017)

Computer-Driven Development of an in Silico Tool for Finding Selective Histone Deacetylase 1 Inhibitors
por: Sirous, Hajar, et al.
Publicado: (2020)

Arginase expression modulates nitric oxide production in Leishmania (Leishmania) amazonensis
por: Acuña, Stephanie Maia, et al.
Publicado: (2017)

Leishmania amazonensis Arginase Compartmentalization in the Glycosome Is Important for Parasite Infectivity
por: da Silva, Maria Fernanda Laranjeira, et al.
Publicado: (2012)

Neutrophils Reduce the Parasite Burden in Leishmania (Leishmania) amazonensis-Infected Macrophages
por: Carmo, Érico Vinícius de Souza, et al.
Publicado: (2010)

Murine Susceptibility to Leishmania amazonensis Infection Is Influenced by Arginase-1 and Macrophages at the Lesion Site
por: Tomiotto-Pellissier, Fernanda, et al.
Publicado: (2021)

RNA-seq transcriptional profiling of Leishmania amazonensis reveals an arginase-dependent gene expression regulation
por: Aoki, Juliana Ide, et al.
Publicado: (2017)

L-arginine availability and arginase activity: Characterization of amino acid permease 3 in Leishmania amazonensis
por: Aoki, Juliana Ide, et al.
Publicado: (2017)

Corrigendum: Murine Susceptibility to Leishmania amazonensis Infection Is Influenced by Arginase-1 and Macrophages at the Lesion Site
por: Tomiotto-Pellissier, Fernanda, et al.
Publicado: (2022)

Computational Tool for Fast in silico Evaluation of hERG K(+) Channel Affinity
por: Chemi, Giulia, et al.
Publicado: (2017)

Sphingolipid Degradation in Leishmania (Leishmania) amazonensis
por: Pillai, Agiesh Balakrishna, et al.
Publicado: (2012)

A Repurposing Approach for Uncovering the Anti-Tubercular Activity of FDA-Approved Drugs with Potential Multi-Targeting Profiles
por: Battah, Basem, et al.
Publicado: (2019)

In Vitro and In Vivo Activity of a Palladacycle Complex on Leishmania (Leishmania) amazonensis
por: Paladi, Carolina de Siqueira, et al.
Publicado: (2012)

Synthesis of 1,2,3-Triazole-Containing Methoxylated Cinnamides and Their Antileishmanial Activity against the Leishmania braziliensis Species
por: dos Santos, Fabíola Suelen, et al.
Publicado: (2023)

Osteopontin in the host response to Leishmania amazonensis
por: Giraud, Emilie, et al.
Publicado: (2019)

Effect of 3-Carene and the Micellar Formulation on Leishmania (Leishmania) amazonensis
por: Silva, Audrey Rouse Soares Tavares, et al.
Publicado: (2023)

Insulin-Like Growth Factor-I Induces Arginase Activity in Leishmania amazonensis Amastigote-Infected Macrophages through a Cytokine-Independent Mechanism
por: Vendrame, Celia Maria Vieira, et al.
Publicado: (2014)

Covalent Reversible Inhibitors of Cysteine Proteases Containing the Nitrile Warhead: Recent Advancement in the Field of Viral and Parasitic Diseases
por: Brogi, Simone, et al.
Publicado: (2022)

The Comparative Genomics and Phylogenomics of Leishmania amazonensis Parasite
por: Tschoeke, Diogo A, et al.
Publicado: (2014)

Tocopherol biosynthesis in Leishmania (L.) amazonensis promastigotes
por: Balanco, José Mário F., et al.
Publicado: (2019)

Design, Synthesis and Antifungal/Insecticidal Evaluation of Novel Cinnamide Derivatives
por: Xiao, Yumei, et al.
Publicado: (2011)

Transcriptional responses of Leishmania (Leishmania) amazonensis in the presence of trivalent sodium stibogluconate
por: Patino, Luz H., et al.
Publicado: (2019)

Activity of alkaloids from Aspidosperma nitidum against Leishmania (Leishmania) amazonensis
por: do Socorro Silva da Veiga, Andreza, et al.
Publicado: (2022)

Visceral leishmaniasis caused by Leishmania (Leishmania) amazonensis associated with Hodgkin’s lymphoma
por: Porto, Victor Bertolo Gomes, et al.
Publicado: (2022)

The green chemistry of chalcones: Valuable sources of privileged core structures for drug discovery
por: Marotta, Ludovica, et al.
Publicado: (2022)

Tamoxifen Is Effective in the Treatment of Leishmania amazonensis Infections in Mice
por: Miguel, Danilo C., et al.
Publicado: (2008)

Subversion and Utilization of Host Innate Defense by Leishmania amazonensis
por: Soong, Lynn
Publicado: (2012)

Activity of Cuban Plants Extracts against Leishmania amazonensis
por: García, Marley, et al.
Publicado: (2012)

Endocytosis and Exocytosis in Leishmania amazonensis Are Modulated by Bromoenol Lactone
por: Fernandes, Anne C. S., et al.
Publicado: (2020)

Biological effects of trans, trans-farnesol in Leishmania amazonensis
por: Pinheiro, Liliane Sena, et al.
Publicado: (2023)

Discovery of Novel Cinnamide Fungicidal Leads with Optical Hydroxyl Side Chain
por: Wang, Weiwei, et al.
Publicado: (2022)

Synthetic Cinnamides and Cinnamates: Antimicrobial Activity, Mechanism of Action, and In Silico Study
por: de Morais, Mayara Castro, et al.
Publicado: (2023)

Identification of Novel 3-Hydroxy-pyran-4-One Derivatives as Potent HIV-1 Integrase Inhibitors Using in silico Structure-Based Combinatorial Library Design Approach
por: Sirous, Hajar, et al.
Publicado: (2019)

Study of the differentially abundant proteins among Leishmania amazonensis, L. braziliensis, and L. infantum
por: Lima, Bruna Soares de Souza, et al.
Publicado: (2020)

The Genome Sequence of Leishmania (Leishmania) amazonensis: Functional Annotation and Extended Analysis of Gene Models
por: Real, Fernando, et al.
Publicado: (2013)

Immucillins Impair Leishmania (L.) infantum chagasi and Leishmania (L.) amazonensis Multiplication In Vitro
por: Freitas, Elisangela Oliveira, et al.
Publicado: (2015)

Effect of phospholipase A(2) inhibitors during infection caused by Leishmania (Leishmania) amazonensis
por: Bordon, Maria L. A. C., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_2qde2bahvm9rqhv1mjqdfjf6ak