Downregulation of the Polycomb-Associated Methyltransferase Ezh2 during Maturation of Hippocampal Neurons Is Mediated by MicroRNAs Let-7 and miR-124

Ezh2 is a catalytic subunit of the polycomb repressive complex 2 (PRC2) which mediates epigenetic gene silencing through depositing the mark histone H3 lysine 27 trimethylation (H3K27me3) at target genomic sequences. Previous studies have demonstrated that Enhancer of Zeste Homolog 2 (Ezh2) was diff...

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Detalles Bibliográficos
Autores principales: Guajardo, Laura, Aguilar, Rodrigo, Bustos, Fernando J., Nardocci, Gino, Gutiérrez, Rodrigo A., van Zundert, Brigitte, Montecino, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7697002/
https://www.ncbi.nlm.nih.gov/pubmed/33187138
http://dx.doi.org/10.3390/ijms21228472

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7697002/
https://www.ncbi.nlm.nih.gov/pubmed/33187138
http://dx.doi.org/10.3390/ijms21228472

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