Mitochondrial Carriers Regulating Insulin Secretion Profiled in Human Islets upon Metabolic Stress

Chronic exposure of β-cells to nutrient-rich metabolic stress impairs mitochondrial metabolism and its coupling to insulin secretion. We exposed isolated human islets to different metabolic stresses for 3 days: 0.4 mM oleate or 0.4 mM palmitate at physiological 5.5 mM glucose (lipotoxicity), high 25...

Descripción completa

Detalles Bibliográficos
Autores principales: Jimenez-Sánchez, Cecilia, Brun, Thierry, Maechler, Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7697104/
https://www.ncbi.nlm.nih.gov/pubmed/33198243
http://dx.doi.org/10.3390/biom10111543

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7697104/
https://www.ncbi.nlm.nih.gov/pubmed/33198243
http://dx.doi.org/10.3390/biom10111543

Ejemplares similares