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Mitochondrial Carriers Regulating Insulin Secretion Profiled in Human Islets upon Metabolic Stress

Chronic exposure of β-cells to nutrient-rich metabolic stress impairs mitochondrial metabolism and its coupling to insulin secretion. We exposed isolated human islets to different metabolic stresses for 3 days: 0.4 mM oleate or 0.4 mM palmitate at physiological 5.5 mM glucose (lipotoxicity), high 25...

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Detalles Bibliográficos
Autores principales:	Jimenez-Sánchez, Cecilia, Brun, Thierry, Maechler, Pierre
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7697104/ https://www.ncbi.nlm.nih.gov/pubmed/33198243 http://dx.doi.org/10.3390/biom10111543

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