ATM Inhibitor Suppresses Gemcitabine-Resistant BTC Growth in a Polymerase θ Deficiency-Dependent Manner

Patients with advanced biliary tract cancer (BTC) inevitably experience progression after first-line, gemcitabine-based chemotherapy, due to chemo-resistance. The genetic alterations of DNA damage repair (DDR) genes are usually determined in BTC tumors. In this study, we found that the POLQ mRNA lev...

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Detalles Bibliográficos
Autores principales: Pan, Yi-Ru, Wu, Chiao-En, Yeh, Chun-Nan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7697425/
https://www.ncbi.nlm.nih.gov/pubmed/33182492
http://dx.doi.org/10.3390/biom10111529

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7697425/
https://www.ncbi.nlm.nih.gov/pubmed/33182492
http://dx.doi.org/10.3390/biom10111529

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