Novel Positive Allosteric Modulators of µ Opioid Receptor—Insight from In Silico and In Vivo Studies

Opioids are the drugs of choice in severe pain management. Unfortunately, their use involves serious, potentially lethal side effects. Therefore, efforts in opioid drug design turn toward safer and more effective mechanisms, including allosteric modulation. In this study, molecular dynamics simulati...

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Detalles Bibliográficos
Autores principales: Bartuzi, Damian, Kędzierska, Ewa, Kaczor, Agnieszka A., Schmidhammer, Helmut, Matosiuk, Dariusz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7697543/
https://www.ncbi.nlm.nih.gov/pubmed/33187107
http://dx.doi.org/10.3390/ijms21228463

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7697543/
https://www.ncbi.nlm.nih.gov/pubmed/33187107
http://dx.doi.org/10.3390/ijms21228463

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