Secondary Functions of Arginine and Sulfur Amino Acids in Poultry Health: Review

SIMPLE SUMMARY: Historically, studies with amino acids have focused on protein synthesis and accretion, especially with eggs and meat, whereas less importance has been given to their secondary functions on the metabolism. However, certain amino acids, such as arginine, methionine, and cysteine are precursors for other essential molecules in the immune defense, antioxidant system, cell signaling, and gene expression, and can act as regulators in the growth and development of the animals. Because poultry are subjected to stressful conditions throughout their lives, the use of these amino acids and their secondary functions could beneficiate their general health. This review describes the metabolism of arginine, methionine, and cysteine and how they modulate different tissues, especially during challenging conditions. Arginine supplementation has been shown to modulate musculoskeletal health development, reduce fat accretion, and improve the antioxidant system. Moreover, methionine and cysteine could improve the bone development and have a potential in mitigating the negative effects caused by heat stress. Understanding how these amino acids can ameliorate stressful conditions may provide novel insights about their use as nutritional strategies to modulate the health status of chickens. ABSTRACT: Amino acids such as arginine, methionine, and cysteine are the precursors of essential molecules that regulate growth and health, being classified as functional amino acids. This review describes the metabolism of arginine and the sulfur amino acids and how they modulate, directly or indirectly, different tissues. Emphasis is placed on their effects in supporting health during challenging conditions, such as heat stress and Eimeria infection. The use of arginine has been shown to reduce abdominal fat pad in ducks and increase lean tissue and bone mineral density in broilers. Additionally, the sulfur amino acids have been shown to improve bone development and are beneficial during heat stress. The use of L-methionine increased the cortical and trabecular bone mineral densities, in laying hens. Moreover, the dietary inclusion of these amino acids could reduce the damage caused by Eimeria spp. infection by regulating the antioxidant system and cell repair. Understanding how these amino acids can mitigate stressful conditions may provide us novel insights of their use as nutritional strategies to modulate the health status of chickens.