Aberrant Bone Homeostasis in AML Is Associated with Activated Oncogenic FLT3-Dependent Cytokine Networks

Acute myeloid leukaemia (AML) is a haematopoietic malignancy caused by a combination of genetic and epigenetic lesions. Activation of the oncoprotein FLT3 ITD (Fms-like tyrosine kinase with internal tandem duplications) represents a key driver mutation in 25–30% of AML patients. FLT3 is a class III...

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Detalles Bibliográficos
Autores principales: Bär, Isabel, Ast, Volker, Meyer, Daria, König, Rainer, Rauner, Martina, Hofbauer, Lorenz C., Müller, Jörg P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7697865/
https://www.ncbi.nlm.nih.gov/pubmed/33182501
http://dx.doi.org/10.3390/cells9112443

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7697865/
https://www.ncbi.nlm.nih.gov/pubmed/33182501
http://dx.doi.org/10.3390/cells9112443

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