Design, Synthesis, and In Vitro/In Vivo Anti-Cancer Activities of Novel (20S)-10,11-Methylenedioxy-Camptothecin Heterocyclic Derivatives

A novel camptothecin analogue, (20S)-10,11-methylenedioxy-camptothecin (FL118), has been proven to show significant antitumor efficacy for a wide variety of solid tumors. However, the further development of FL118 is severely hindered due to its extremely poor water solubility and adverse side effect...

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Detalles Bibliográficos
Autores principales: Dai, Xiufen, Wu, Guanzhao, Zhang, Yixuan, Zhang, Xiaomin, Yin, Ruijuan, Qi, Xin, Li, Jing, Jiang, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7697887/
https://www.ncbi.nlm.nih.gov/pubmed/33187360
http://dx.doi.org/10.3390/ijms21228495

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7697887/
https://www.ncbi.nlm.nih.gov/pubmed/33187360
http://dx.doi.org/10.3390/ijms21228495

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