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Design, Synthesis, and In Vitro/In Vivo Anti-Cancer Activities of Novel (20S)-10,11-Methylenedioxy-Camptothecin Heterocyclic Derivatives

A novel camptothecin analogue, (20S)-10,11-methylenedioxy-camptothecin (FL118), has been proven to show significant antitumor efficacy for a wide variety of solid tumors. However, the further development of FL118 is severely hindered due to its extremely poor water solubility and adverse side effect...

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Detalles Bibliográficos
Autores principales:	Dai, Xiufen, Wu, Guanzhao, Zhang, Yixuan, Zhang, Xiaomin, Yin, Ruijuan, Qi, Xin, Li, Jing, Jiang, Tao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7697887/ https://www.ncbi.nlm.nih.gov/pubmed/33187360 http://dx.doi.org/10.3390/ijms21228495

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