Molecular Modeling, Synthesis and Biological Evaluation of N-Phenyl-4-Hydroxy-6-Methyl-2-Quinolone-3-CarboxAmides as Anticancer Agents

The emergence of phosphatidylinositol 3-kinase (PI3Kα) in cancer development has accentuated its significance as a potential target for anticancer drug design. Twenty one derivatives of N-phenyl-4-hydroxy-6-methyl-2-quinolone-3-carboxamide were synthesized and characterized using NMR ((1)H and (13)C...

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Detalles Bibliográficos
Autores principales: Sabbah, Dima A., Hasan, Shaima’ E., Abu Khalaf, Reema, Bardaweel, Sanaa K., Hajjo, Rima, Alqaisi, Khalid M., Sweidan, Kamal A., Al-Zuheiri, Aya M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7698136/
https://www.ncbi.nlm.nih.gov/pubmed/33207767
http://dx.doi.org/10.3390/molecules25225348

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7698136/
https://www.ncbi.nlm.nih.gov/pubmed/33207767
http://dx.doi.org/10.3390/molecules25225348

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