Potent Quinoline-Containing Combretastatin A-4 Analogues: Design, Synthesis, Antiproliferative, and Anti-Tubulin Activity

A novel series of quinoline derivatives of combretastatin A-4 incorporating rigid hydrazone and a cyclic oxadiazole linkers were synthesized and have demonstrated potent tubulin polymerization inhibitory properties. Many of these novel derivatives have shown significant antiproliferative activities...

Descripción completa

Detalles Bibliográficos
Autores principales: Ibrahim, Tarek S., Hawwas, Mohamed M., Malebari, Azizah M., Taher, Ehab S., Omar, Abdelsattar M., O’Boyle, Niamh M., McLoughlin, Eavan, Abdel-Samii, Zakaria K., Elshaier, Yaseen A. M. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7698209/
https://www.ncbi.nlm.nih.gov/pubmed/33203182
http://dx.doi.org/10.3390/ph13110393

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7698209/
https://www.ncbi.nlm.nih.gov/pubmed/33203182
http://dx.doi.org/10.3390/ph13110393

Ejemplares similares