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Synthesis of Conformationally Constrained d-Glu-meso-DAP Analogs as Innate Immune Agonists
The dipeptide d-Glu-meso-DAP (iE-DAP) is the minimal structural fragment capable of activating the innate immune receptor nucleotide-binding oligomerization domain protein (NOD1). The meso-diaminopimelic acid (meso-DAP) moiety is known to be very stringent in terms of the allowed structural modifica...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7698283/ https://www.ncbi.nlm.nih.gov/pubmed/33182604 http://dx.doi.org/10.3390/molecules25225228 |