Design, Synthesis, and Biological Evaluation of Pyridazinones Containing the (2-Fluorophenyl) Piperazine Moiety as Selective MAO-B Inhibitors

Twelve pyridazinones (T1–T12) containing the (2-fluorophenyl) piperazine moiety were designed, synthesized, and evaluated for monoamine oxidase (MAO) -A and -B inhibitory activities. T6 was found to be the most potent MAO-B inhibitor with an IC(50) value of 0.013 µM, followed by T3 (IC(50) = 0.039 µ...

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Detalles Bibliográficos
Autores principales: Çeçen, Muhammed, Oh, Jong Min, Özdemir, Zeynep, Büyüktuncel, Saliha Ebru, Uysal, Mehtap, Abdelgawad, Mohamed A., Musa, Arafa, Gambacorta, Nicola, Nicolotti, Orazio, Mathew, Bijo, Kim, Hoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7698448/
https://www.ncbi.nlm.nih.gov/pubmed/33212876
http://dx.doi.org/10.3390/molecules25225371

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7698448/
https://www.ncbi.nlm.nih.gov/pubmed/33212876
http://dx.doi.org/10.3390/molecules25225371

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