Integrity of the Antiviral STING-mediated DNA Sensing in Tumor Cells Is Required to Sustain the Immunotherapeutic Efficacy of Herpes Simplex Oncolytic Virus

SIMPLE SUMMARY: Oncolytic viruses are emerging immunotherapeutics in cancer treatments. The conflicting role of innate immunity in the antitumor activity of oncolytic viruses is still a matter of debate. The STING-dependent DNA sensing axis is considered detrimental for viral replication and cancer...

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Detalles Bibliográficos
Autores principales: Froechlich, Guendalina, Caiazza, Carmen, Gentile, Chiara, D’Alise, Anna Morena, De Lucia, Maria, Langone, Francesca, Leoni, Guido, Cotugno, Gabriella, Scisciola, Vittorio, Nicosia, Alfredo, Scarselli, Elisa, Mallardo, Massimo, Sasso, Emanuele, Zambrano, Nicola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7698602/
https://www.ncbi.nlm.nih.gov/pubmed/33213060
http://dx.doi.org/10.3390/cancers12113407

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7698602/
https://www.ncbi.nlm.nih.gov/pubmed/33213060
http://dx.doi.org/10.3390/cancers12113407

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