Mutant Kras as a Biomarker Plays a Favorable Role in FL118-Induced Apoptosis, Reactive Oxygen Species (ROS) Production and Modulation of Survivin, Mcl-1 and XIAP in Human Bladder Cancer

SIMPLE SUMMARY: FL118 is a novel orally available small molecule anticancer drug. We found that bladder cancer cells with a mutant Kras is highly sensitive to FL118-induced cell growth inhibition and cell death induction through inhibiting the anti-cancer cell death and drug resistance factors (surv...

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Detalles Bibliográficos
Autores principales: Santha, Sreevidya, Ling, Xiang, Aljahdali, Ieman A. M., Rasam, Sailee S., Wang, Xue, Liao, Jianqun, Wang, Jue, Fountzilas, Christos, Li, Qingyong, Qu, Jun, Li, Fengzhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7698790/
https://www.ncbi.nlm.nih.gov/pubmed/33217967
http://dx.doi.org/10.3390/cancers12113413

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7698790/
https://www.ncbi.nlm.nih.gov/pubmed/33217967
http://dx.doi.org/10.3390/cancers12113413

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