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Discovery and Design of Novel Small Molecule GSK-3 Inhibitors Targeting the Substrate Binding Site
The serine/threonine kinase, GSK-3, is a promising drug discovery target for treating multiple pathological disorders. Most GSK-3 inhibitors that were developed function as ATP competitive inhibitors, with typical limitations in specificity, safety and drug-induced resistance. In contrast, substrate...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7698860/ https://www.ncbi.nlm.nih.gov/pubmed/33218072 http://dx.doi.org/10.3390/ijms21228709 |